2 edition of synthesis of novel oligonucleoside isosteres. found in the catalog.
synthesis of novel oligonucleoside isosteres.
Ben James Mellor
Thesis (Ph.D.), - University of Manchester, Department of Chemistry.
|Contributions||University of Manchester. Department of Chemistry.|
|The Physical Object|
|Number of Pages||150|
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We describe here the synthesis of 9-[2-(Boranophosphonomethoxy)ethyl]adenine (6a) and (R)[2-(Boranophosphonomethoxy)propyl]adenine (6b), the first α-boranophosphonate nucleosides in which a borane (BH3) group substitutes one nonbridging oxygen atom of the α-phosphonate moiety.
H-phosphinates 5a and 5b and α-boranophosphonates 6a and 6b were evaluated for their in vitro. What were the titles of the James bond novel written by ian flemming.
'The synthesis of novel oligonucleoside isosteres' Asked in Authors, The book Noble Housewas written by James Clavell. Substitution of a borano (BH3-) group for nonbridging oxygen in the phosphate backbone of DNA results in a new class of isoelectronic and isoionic DNA analogues.
An effective chemical method of synthesis of oligodeoxynucleoside boranophosphates (BH3-−ODNs) on a solid phase has been developed via an H-phosphonate chain elongation approach followed by vintage-memorabilia.com by: Abstract. The artificial control of gene expression by modified oligonucleotides (ONs) provides an exciting opportunity for the rational design of antisense ONs and, in particular, for the design of antiviral and antitumor ONs that can be used for therapeutic purposes.
1 The effectiveness of antisense ONs in vitro and in vivo has been demonstrated by a first generation of phosphate-modified Cited by: Nov 05, · Abstract. This review covers recent progress in the preparation of H-phosphonate mono- and diesters, basic studies on mechanistic and stereochemical aspects of this class of phosphorus compounds, and their fundamental chemistry in terms of transformation of P–H bonds into P-heteroatom vintage-memorabilia.comed recent applications of H-phosphonate derivatives in basic organic phosphorus Cited by: 9.
All that we know about terran life suggests that it exists in water at nearly neutral internal pH and at a range of temperatures that permits water to be in the liquid state.
That range includes temperatures higher than °C, the boiling point of pure water at sea level, if pressures higher than 1. Diadenosine and Diuridine Poly(borano)phosphate Analogues: Synthesis, Chemical and Enzymatic Stability, and Activity at P2Y 1 and P2Y 2 Receptors †.
Adenosine 5‘- O -(1-Boranotriphosphate) Derivatives as Novel P2Y 1 Receptor Agonists Article in Journal of Medicinal Chemistry 45(24) · December with 19 Reads How we measure 'reads'.
Feb 06, · Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected nucleoside sequence wherein the. Aug 11, · Further as per further examples of the specification, the oxime linked dimer is reduced to a dimer bearing a corresponding hydroxylamine linkage and this in turn can be alkylated to a hydroxylmethylamine or other hydroxyalkylamine linkage.
EXAMPLE Synthesis of (3'-CH NH--O--CH ') linked oligonucleoside. Inhe joined Dr. Raymond F. Schinazi at Emory University (Atlanta, GA) as a Postdoctoral Fellow where he focused on the synthesis of nucleoside phosphate and phosphonate prodrugs targeting HCV inhibition with an emphasis on the conversion of furanonucleoside analogs into their corresponding phosphonate prodrug vintage-memorabilia.com by: The Workshop on the Limits of Organic Life in Planetary Systems was held on May, at the Constitution Avenue building of the National Academies, Washington, D.C.
In the design of amide bond isosteres several important factors have to be considered. The isosteres have to mimic the amide geometrically and electrostatically, and should also show similar conformational flexibility and hydrogen bonding properties.
A previously reported Phe-Gly fluorovinyl isostere exhibits good mimicking ability . It is not possible to give an overview of the evolution of the different aspects of nucleic acids chemistry and their applications within the context of one book. The aim of Oligonucleotide Synthesis: Methods and Applications is to give the readers an insight into new key developments and to deliver protocols and critical comments for the.
Interest is growing in the synthesis and structural characterisation of phosphido-derivatives of aluminium,52 gallium, and indium,5 8, 5 9 since thermal decomposition of such compounds may offer novel routes for the preparation of metallophosphide electronic devices.
C — CHEMISTRY; METALLURGY; C12 — BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING; C12N — MICROORGANISMS OR Author: D·威纳, P·路金布厄, A·布埃诺, J·昆卡, E·马拉斯科.